In addition to playing its core role in anti-aging, NMN has shown certain potential in weight loss, and its mechanisms mainly include:
promoting cell metabolism, regulating intestinal flora balance, affecting appetite and energy intake, accelerating fat decomposition and so on.
A study published in April 2021 in the academic journal 《Scientific Reports》 did bring good news to the weight loss field.
The researchers found that supplementation with NMN (niacinamide mononucleotide) was able to positively affect the metabolic state of fat cells by activating the "longevity protein" SIRT1, showing great potential as a potential weight loss method.
In 2021, the team of Japanese scientist Professor Shin-Ichiro Imai published the results of a clinical trial study on NMN (niacinamide mononucleotide) in the authoritative academic journal 《Science》, which did confirm the effectiveness of NMN in improving glucose tolerance in pre-diabetic women.
In 2023, a study published in 《Clinical Nutrition ESPEN》 by Osaka University in Japan showed that oral administration of 250 mg of NMN per day for three months significantly increased plasma NAD+ levels and increased serum insulin levels five-fold. This suggests that NMN can play a positive role in the prevention of diabetes.
In 2023, David Sinclair's research team at Harvard Medical School published The results of a study on NMN (niacinamide mononucleotide) in 《The Journal of Clinical Endocrinology & Metabolism》.
Compared with participants who did not receive NMN, the NMN subjects lost more than 6 pounds (about 2.72 kg) in weight, indicating that NMN has a significant weight loss effect on overweight or obese adults.
NMN not only reduces total cholesterol levels, but also significantly reduces levels of low-density lipoprotein cholesterol (LDL-C), which is strongly associated with vascular cholesterol buildup and cardiovascular disease risk.
In April 2023, research published online in 《Biochemistry and Biophysics Reports》 by the Graduate School of Integrative Pharmaceutical and Nutritional Sciences of Shizuoka University, Japan, further confirmed the remarkable effect of NMN in fat loss.
It was found that NMN was able to significantly reduce subcutaneous fat mass and fat cell size. This finding provides strong support for the application of NMN in the field of fat reduction. The study further revealed the potential mechanism of NMN fat loss.
Although multiple studies have shown that NMN shows some potential for weight loss, its effects are not immediate. Weight loss is a complex process that requires a comprehensive consideration of diet, exercise, lifestyle and other aspects.