In terms of improving mitochondrial health and anti-aging, NADH, resveratrol, astaxanthin, Coenzyme Q10, urolitin A, and spermidine are all supplements of concern. However, each supplement has its own unique mechanisms and advantages.
1. NADH
Main role:
NADH can efficiently generate NAD+ in the body, and NAD+ is a key molecule in the process of cell material metabolism and mitochondrial energy production.
Anti-aging mechanisms:
By boosting NAD+ levels, NADH activates the longevity protein SIRT1, adjusts the body clock, activates neurotransmitters, and regulates sleep mechanisms. In addition, NADH can also repair damaged DNA, antioxidant, improve the level of human metabolism, so as to achieve a comprehensive effect of anti-aging.
Advantages:
NADH is recognized and recommended by NASA for use by astronauts to regulate the body clock, showing its effectiveness in practical applications.
2. Resveratrol
Main role:
Resveratrol is a plant-based polyphenol that has antioxidant and anti-inflammatory properties.
Anti-aging mechanisms:
Resveratrol can activate cell regulatory enzymes sirtuins, promote the formation of new mitochondria and increase the energy produced by mitochondria. It also restores autophagy and removes toxic cellular waste and debris that accumulates with age.
Advantages:
Resveratrol is considered a powerful mTOR inhibitor and may be a good option for people looking to reap the benefits of caloric restriction without dieting.
3. Astaxanthin
Main role:
Astaxanthin is a red beta-violone ring carotenoid with extremely high antioxidant activity.
Anti-aging mechanisms:
Astaxanthin can quench singlet oxygen, remove free radicals, and maintain mitochondrial function by protecting mitochondrial REDOX balance. In addition, it can also improve the activity of superoxide dismutase and glutathione peroxidase.
Advantages:
Astaxanthin has 6,000 times the antioxidant capacity of vitamin C and 550 times that of vitamin E, showing its powerful antioxidant potential.
4. CoQ10 (CoQ10)
Main role:
Coenzyme Q10 is the energy conversion agent of cell mitochondria, and is also a classic anti-aging nutrient widely recognized by the scientific community.
Anti-aging mechanisms:
Coenzyme Q10 has a powerful antioxidant capacity that can scavenge free radicals and help restore the antioxidant activity of vitamins C and E that have been oxidized. In addition, it provides adequate oxygen and energy for heart muscle cells and brain cells.
Advantages:
CoQ10 is particularly important in heart health and has been shown to improve symptoms of heart failure and reduce mortality and hospitalization rates in patients with heart failure.
5. Urolithin A (UA)
Main role:
Urolixin A is a secondary metabolite produced by intestinal bacteria metabolizing polyphenols.
Anti-aging mechanisms:
Urolixin A can activate sirtuins, increase NAD+ and cellular energy levels, and clear damaged mitochondria from human muscles. In addition, it also has anti-inflammatory, anti-proliferation and other effects.
Advantages:
Urolixin A is able to cross the blood-brain barrier and has the potential to improve metabolic diseases and anti-aging.
6. Spermidine
Main role:
Spermidine is a naturally occurring molecule that is produced by gut bacteria.
Anti-aging mechanisms:
Spermidine can trigger mitochondrial autophagy and remove unhealthy damaged mitochondria. In addition, it has the potential to prevent heart disease and reproductive aging in women.
Advantages:
Dietary spermidine is found in a variety of foods, such as soy and grains, and is easy to obtain.
------From scientific knowledge from mitochondria