The world's richest man, Jeff Bezos, has invested in the anti-aging company Altos. Silicon Valley tech tycoon Brian Johnson has hired a professional team of over 30 people and spends $2 million annually to "return to youth". Professor David Sinclair from Harvard Medical School uses research to verify popular anti-aging ingredients.
Many business celebrities and stars are also willing to invest heavily in maintenance.
Among the anti-aging lists of global celebrities, there are some commonalities. For instance, they all incorporate scientific supplementation of important anti-aging nutrients. By studying their anti-aging lists, we have identified the top 5 essential supplements that frequently appear. These might also serve as your own youthful secret.
01、Coenzyme Q10
When it comes to coenzyme Q10, many people immediately think of its role in protecting the heart or cardiovascular health, and thus often assume that only the elderly need to take coenzyme Q10 supplements.
In fact, coenzyme Q10 exists in all organs and tissues of the human body and is the "energy catalyst" in the cell mitochondria. In short, coenzyme Q10 is an indispensable substance for cellular energy production, making it an important basic supplement for anti-aging.
The research [1] reveals that the peak level of coenzyme Q10 in the human body occurs at the age of 20. After that, it keeps declining. By the age of 50, the content of coenzyme Q10 in the body has decreased by 20% compared to that at the age of 20, and by the age of 70, it will have decreased by approximately 57%.
The core value of coenzyme Q10 is mainly reflected in three aspects:
●Energy catalyst:
Mitochondria are known as the energy factory of the cell. The important role of coenzyme Q10 is to participate in the production of cellular energy within the mitochondrial respiratory chain.
Therefore, coenzyme Q10 is particularly abundant in "high-energy-consuming" organs and tissues, such as the heart, liver, kidneys, and muscles. This is why coenzyme Q10 has a very obvious enhancing effect on exercise, as it can significantly enhance physical performance, accelerate the recovery from fatigue after exercise, and reduce muscle soreness.
● Antioxidant Guardian:
As is well known, oxidative stress damage is one of the main causes of aging. Coenzyme Q10 is a lipid-soluble antioxidant present in cells, which can protect cells from oxidative damage and is an essential substance for maintaining health.
The antioxidant effect of Coenzyme Q10 is particularly prominent in cardiovascular health and cognitive function [2].
Therefore, the American College of Cardiology recommends that people over 65 years old, regardless of whether they have heart disease or not, should take Coenzyme Q10 every day.
The "Chinese Residents Dietary Nutrient Reference Intakes (2023 Edition)" also states that supplementing with 100mg or more of Coenzyme Q10 daily can significantly improve oxidative stress damage.
● Immunomodulators:
Immune health is closely related to human aging.
Young people often suffer from viral infections easily, staying up late accelerates aging, and all these phenomena are related to the decline of the body's immune function.
Research [3] found that by supplementing 200mg of coenzyme Q10 daily for 3 consecutive months, the activity of important immune cells, NK cells, can be improved.
In addition, the immune system also requires sufficient energy to function properly. When facing various external viral infections, the immune response will consume a large amount of coenzyme Q10.
Therefore, supplementing coenzyme Q10 can help shorten the infection period and accelerate physical recovery.
Representatives of celebrities：
Tesla CEO Elon Musk, Silicon Valley tech tycoon Brian Johnson, Silicon Valley investor Dave Asprey, scientist Karl Folkers, supermodel Gisele Bündchen
Additional Suggestions ：
Daily health care: 100mg per day Anti-aging and health care for high-risk groups: 200mg per day It is recommended to take it with the meal.
02、 Omega-3 fatty acids
Omega-3 is a group of polyunsaturated fatty acids, and its three key components are EPA, DHA, and DPA. The core anti-aging effect of Omega-3 is anti-inflammation, which has positive effects on cardiovascular health, brain health, joint health, and other aspects.
●The leader in the anti-inflammatory field:
Chronic inflammation is regarded as the root cause of aging and chronic diseases. Therefore, anti-inflammatory diets have become a very popular anti-aging diet method in recent years.
Omega-3 helps reduce chronic inflammation throughout the body, improve vascular elasticity, and lower the risk of heart disease. It is a widely recognized basic supplement for anti-aging.
● Cardiovascular Health Support:
The article "Omega-3 Fatty Acids and Cardiovascular Diseases - New Recommendations from the American Heart Association [4]" states that in randomized clinical trials of patients with coronary heart disease, Omega-3 fatty acid supplements significantly reduced cardiovascular events and could also slow the progression of atherosclerosis.
The World Health Organization as well as China, Japan, the United States, Canada, the United Kingdom, and Australia have all proposed dietary recommendations regarding the supplementation of Omega-3 fatty acids.
Among the key components of Omega-3, previously people mainly focused on EPA and DHA. However, recent studies have found [5] that the anti-atherosclerotic effect of DPA is 10 times that of EPA.
Representatives of celebrities：
The world's richest man Jeff Bezos, Silicon Valley tech tycoon Brian Johnson, medical doctor Carla Fitzgerald, and NBA legend LeBron James
Additional Suggestions ：
Consume 2-3 servings of deep-sea fish (such as salmon, sardines, cod, etc.) per week, or take Omega-3 supplements (1-3 grams per day), such as fish oil or seal oil. It is recommended to take it with the meal.
It should be noted that highly concentrated Omega-3 supplements are not the best choice. The process of high-concentration extraction alters the properties of the fatty acids, and they are less easily absorbed and utilized by the human body compared to those in their natural proportions.
03、Vitamin D
The most widely recognized function of vitamin D is to promote calcium absorption and maintain bone health.
Therefore, children, pregnant women, the elderly, and others are regarded as key groups for supplementation. In fact, vitamin D is not only a "helper for calcium absorption", but also an "all-round player" that regulates immunity and endocrine systems.
Unlike many other vitamins, the amount of vitamin D that humans can obtain from food is very limited.
The human body mainly generates vitamin D by exposing its skin to ultraviolet rays in sunlight. However, if one spends a lot of time indoors, lacks outdoor activities, or strictly uses sunscreen, it will affect the synthesis of vitamin D.
Long-term deficiency of vitamin D may lead to: osteoporosis, weakened immunity, anxiety, sleep disorders, etc.
Vitamin D plays a significant role in enhancing the immune function of cells and regulating physiological processes, and it can reduce the risk of upper respiratory tract infections.
Studies have shown [6] that vitamin D deficiency can increase the risk of COVID-19 infection by 77%, and this trend is more pronounced in women.
The infection probability is as follows: women lacking vitamin D > men lacking vitamin D > those without vitamin D deficiency.
Furthermore, vitamin D may be associated with melatonin. Vitamin D deficiency is also linked to sleep disorders and poor sleep quality.
Representatives of celebrities：
Silicon Valley tech tycoon Brian Johnson, YouTube's well-known health blogger Joe Rogan, and scientist Reinhold Vieth
Additional Suggestions ：
Vitamin D supplements come in D2 and D3 forms. Vitamin D3 has a higher bioavailability and is the preferred supplement for vitamin D deficiency.
Dietary supplements recommend 400-800 IU per day. Higher doses should be consulted with a doctor or nutritionist first.
It is recommended to take it with the meal. It works better when exposed to moderate sunlight.
04、 NAD+ supplement
NAD+ is the full name of nicotinamide adenine dinucleotide, which is the first coenzyme in the human body.
Numerous biochemical reactions in the human body require the participation of NAD+.
Without NAD+, a person would die within 30 seconds.
A large number of scientific studies have found that NAD+ plays an irreplaceable role in cellular energy metabolism, mitochondrial energy supply, DNA damage repair, activation of longevity proteins, and aging regulation， and is a key factor determining human aging [7].
The discovery of NAD+ dates back to 1904. However, due to the fact that NAD+ cannot be replenished directly, significant progress in related anti-aging supplements was not achieved until later. For instance, its reduced form NADH and its precursor substance NMN, etc.
With the breakthroughs in the research of these supplements, NAD+ supplements have emerged as a dominant force, attracting the attention of both the scientific community and the general public.
Not only have numerous studies been published in top international journals, but they have also become highly sought-after anti-aging supplements.
Because NAD+ plays an indispensable role in the cell's anti-aging process, it exhibits a wide range of anti-aging effects, such as combating fatigue, enhancing energy, improving sleep, strengthening immunity, delaying ovarian aging, regulating blood sugar, having positive effects on cardiovascular and neurological health, improving skin condition, regulating endocrine and bone health, protecting the health of human organs, and fighting tumors, etc.
Representatives of celebrities：
Professor David Sinclair from Harvard Medical School, Asia's richest man Li Ka-shing, Silicon Valley tech tycoon Brian Johnson, Google technical director Ray Kurzweil, American actress Jennifer Aniston, independent musician Graham, and American professional football player Austin Matsuzaka
Additional Suggestions ：
NMN and NADH are both excellent NAD+ supplements, but their metabolic pathways are different.
NMN is the precursor of NAD+, which needs to be converted into NAD+ in the human body.
NADH is the reduced form of NAD+, which can be directly converted. Therefore, the dosages of the two are also different.
NMN is recommended at 200-600mg per day.
NADH is recommended at 10-30mg per day.
It can be taken on an empty stomach or with meals. Combining with exercise or intermittent fasting will yield better results.
05、 Melatonin
In recent years, on the anti-aging front, the sales of ergothioneine supplements have grown rapidly, and at the same time, new achievements have been continuously made in related anti-aging research.
Ergothioneine is a rare natural sulfur-containing amino acid with powerful anti-aging and antioxidant properties.
Due to this characteristic, ergothioneine was initially favored by top skincare products and became a star ingredient for protecting the skin from UV damage and whitening and reducing pigmentation.
In the field of dietary supplements, the anti-aging effects of ergothioneine have also been continuously discovered.
The renowned biochemist, an honorary professor of biochemistry and molecular biology at the University of California, Berkeley, Bruce Ames, classifies ergothioneine as a "longevity vitamin", believing that ergothioneine is a nutrient that is crucial for maintaining long-term health and preventing chronic diseases.
The latest research conducted in 2025 [8] revealed that in animal experiments, ergothioneine not only extended the lifespan by 20%, but also improved the health span of the elderly animals.
They not only lived longer but also remained healthier. Moreover, ergothioneine can significantly increase the NAD+ level in muscles, providing further evidence for its anti-aging effects.
The natural source of ergothioneine is microorganisms (such as non-yeast fungi, actinomycetes, cyanobacteria, etc.). The human body cannot synthesize ergothioneine on its own and can only obtain it through food intake.
Generally, mushrooms contain relatively abundant ergothioneine. However, a comparative study on the content of bioactive components in mushrooms [9] shows that, except for the straw mushroom which has a value of 537.3 milligrams per kilogram (dry weight), the content of ergothioneine in many common mushrooms is not very high.
Due to the high purine content in mushrooms, relying solely on dietary supplementation may lead to high purine levels. Therefore, ergothioneine supplements become the preferred option.
Representatives of celebrities：
Silicon Valley tech tycoon Brian Johnson, renowned biochemist Bruce Ames, anti-aging expert Barry Halliwell
Additional Suggestions ：
Daily health care: 25 - 50 mg per day. It is recommended to take it with the meal.
Aging detection becomes a new method Apart from making scientifically chosen anti-aging supplements, there is also a relatively mature system for verifying anti-aging effects at present, such as NAD+ concentration testing and biological age detection using epigenetic clocks. Silicon Valley tech tycoon Brian Johnson spent a large sum of money to hire an anti-aging team, and they adopted the epigenetic clock detection technology. After 7 months, their biological age decreased by 5.1 years.
the article from 《Life knows the right time. 》
[1] Age-related changes in the lipid compositions of rat and human tissues. DOI:10.1007/BF02535072
[2] Coenzyme Q10Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases. doi:10.3390/ijms21217870
[3]Markers of innate immune activity in patients with type 1 and type 2 diabetes mellitus and the effect of the anti-oxidant coenzyme Q10 on inflammatory activity. DOI:10.1111/cei.12316
[4] Penny M. Kris-Etherton, William S. Harris, Lawrence J. Appel. Omega-3 Fatty Acids and Cardiovascular Disease: New Recommendations From the American Heart Association.
[5] Docosapentaenoic acid (22:5, n-3), an elongation metabolite of eicosapentaenoic acid (20:5, n-3), is a potent stimulator of endothelial cell migration on pretreatment in vitro. DOI:10.1016/s0952-3278(96)90045-9
[6] Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results. DOI: 10.1001/jamanetworkopen.2020.19722
[7] The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways. doi: 10.1210/er.2009-0026
[8] Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation. DOI: 10.1016/j.cmet.2024.12.008
[9] Yu-Chang Lo, Shin-Yi Lin, et al. Comparative Study of Contents of Several Bioactive Components in Fruiting Bodies and Mycelia of Culinary-Medicinal Mushrooms. International Journal of Medicinal Mushrooms, 14(4): 357–363 (2012)