Many friends are often particularly concerned about the content of NMN, such as 13000,25000, or even more content, in fact, under the premise of the same purity and quality of NMN, the natural effect of high content will be better, however, if you ignore the transformation of this step, may not be able to achieve the desired effect.
Today, I will talk about an aspect that we have not paid much attention to, which is the transformation process of NMN, in which the activation of NMNAT and NAMPT transferase activity is very important. The good news for tea and coffee lovers is that tea polyphenols and caffeine also help activate transferase.
These enzymes play a key role in the conversion of NMN (β-nicotinamide mononucleotide) to NAD+ (nicotinamide adenine dinucleotide).
Studies have shown that certain components of caffeine, such as cAMP (cyclic adenosine phosphate), are able to activate the activity of transferases such as NMNAT. These enzymes are key catalysts in the conversion of NMN to NAD+, and their enhanced activity means that the conversion efficiency of NMN will be improved. In addition, other components in coffee, such as tea polyphenols, are also thought to help activate transferase, further promoting the conversion and utilization of NMN.
Coffee accelerates the conversion process of NMN to NAD+ by activating transferase. NAD+ is an important coenzyme in cells that is involved in a variety of biochemical reactions and is essential for maintaining cell health and function.
Supplementing NMN to improve the level of NAD+ in vivo is a hot research topic in the field of anti-aging in recent years. As a daily drink, if coffee can play an active role in this process, it will undoubtedly greatly promote the supplement effect of NMN. You can drink coffee or tea to swallow NMN.
In addition, trigonelline in NMN also plays a very important role. On March 19, 2024, Researchers from the National University of Singapore's Yeo Luling School of Medicine and the Swiss Federal Institute of Technology published a paper in the journal "Nature Metabolism "entitled "Trigonelline is an NAD+ precursor that improves muscle. function during ageing and is reduced in human sarcopenia "research paper.
The study showed that supplementing trigonelline can increase NAD+ levels and increase mitochondrial activity, helping to improve the aging process.
In C. elegans, trigonelline supplementation increases mitochondrial activity, reduces age-related muscle atrophy, and extends lifespan. In mice, fenugreek supplementation increased muscle strength and prevented fatigue during aging.
Trigonelline is found in coffee。